In addition to HSC Haltern-Sythen, 60 other teams from 9 different countries played in Girls 18. They were divided into 10 different groups, whereof HSC Haltern-Sythen could be found in Group 10 together with Raelingen/Skjetten Håndball Red, Skanderborg HB 2, H43 Lund, Enköpings HF and BRH 2. HSC Haltern-Sythen continued to B-Play-off after reaching 5:th place in Group 10. In the playoff they made it to 1/16 Final, but lost it against Skødstrup Håndbold with 12-17. In the Final, Kärra HF won over Raelingen/Skjetten Håndball Green and became the winner of B-Play-off in Girls 18. HSC Haltern-Sythen also participated in Girls 18 during Partille Cup 2022. They reached the 1/16 Final in G18 B-Play-off, but lost it against Särökometernas HK with 12-29.